In a study of women with bone metastases from breast cancer, Xgeva™ (denosumab) delayed bone complications for five months longer than Zometa® (zoledronic acid). These updated results from a Phase III clinical trial were presented at the 2010 San Antonio Breast Cancer Symposium.
Metastatic cancer refers to cancer that has spread to distant sites in the body. Several types of cancer—including breast cancer—have a tendency to spread to the bone. Bone metastases can lead to serious problems such as fracture and spinal cord compression and may require treatment with surgery or radiation therapy.
Bisphosphonate drugs such as Zometa are commonly used to reduce the risk of complications from bone metastases. Researchers continue, however, to explore new approaches to treatment.
Xgeva is a drug that targets a protein known as the RANK ligand. This protein regulates the activity of osteoclasts (cells that break down bone). Xgeva was recently approved for the prevention of bone complications such as fracture in patients with bone metastases from solid (not blood-related) cancers.
To directly compare Xgeva to Zometa among breast cancer patients with bone metastases, researchers conducted a Phase III clinical trial among more than 2,000 patients. Study participants were assigned to receive either Xgeva or Zometa. Zometa is given intravenously, and Xgeva is given as a subcutaneous (under-the-skin) injection.
The objective of the study was to determine whether the occurrence of bone complications (“skeletal related events”) differed between the two study groups. The bone complications that were evaluated were fracture, radiation to the bone, surgery to the bone, and spinal cord compression.
The results of this study suggest that Xgeva is more effective than Zometa at delaying or preventing skeletal complications in breast cancer patients with bone metastases.
Reference: Stopeck A, Martin M, Ritchie D et al. Effect of denosumab versus zoledronic acid treatment in patients with breast cancer and bone metastases: results from the extended blinded treatment phase. Presented at the 33rd annual San Antonio Breast Cancer Symposium, December 8-12, 2010. Abstract P6-14-01.
Copyright © 2016 CancerConsultants. All Rights Reserved.
[ imitation viagra | cheap generic viagra | buy viagra in canada | buy viagra low cost | female herbal viagra | how to get viagra no prescription | cialis next day | viagra patent | stores that sell viagra | soft cialis | advice viagra | purchasing viagra in canada | canada cheap viagra | cialis generic viagra | cialis from mexico | what is cialis | cialis price 100 mg | cialis vs levitra | viagra in india | can teens take viagra | discount phentermine viagra | cialis next day | cialis brand name | cialis usa | can i get viagra in mexico | ordering viagra overnight delivery | cheapest viagra anywhere | cialis samples in canada | alternative search viagra | can teens take viagra | viagra price germany | viagra with no prescription | viagra uk purchase | buying viagra online | low cost viagra | sildenafil citrate | cheapest viagra in uk | map | viagra faq | viagra fast | viagra sales u.k | cialis tablets foreign | generic supplier viagra | viagra original pfizer order | discount viagra sales online | bad side effects of viagra | when do i use cialis | buy porn viagra | viagra without prescription | cialis order | alternate to viagra | cialis generic | generic viagra in mexico | cheap viagra ]